spqb/adabmDCA
adabmDCA 2.0 – a flexible but easy-to-use package for Direct Coupling Analysis
This tool helps computational biologists and biophysicists analyze protein sequences to understand how different parts of a protein interact. You input multiple sequence alignments of a protein family, and it calculates direct coupling scores between amino acid pairs, which can reveal crucial residue contacts or co-evolutionary relationships. Researchers can use this to predict protein structure, identify functional sites, or understand mutational effects.
No commits in the last 6 months. Available on PyPI.
Use this if you need to perform Direct Coupling Analysis (DCA) on protein multiple sequence alignments to infer residue-residue contacts and understand protein co-evolution.
Not ideal if you are looking for a general-purpose sequence alignment tool or need to analyze data types other than protein multiple sequence alignments.
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Jul 04, 2025
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