westlake-repl/ProteinLM-TDG2-Mutation
Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing
This project helps molecular biologists and genetic engineers optimize uracil-N-glycosylase variants for precise gene editing. By inputting protein sequences, you get predicted single mutations that enable specific T-to-G and T-to-C base changes. This allows researchers to strategically modify DNA sequences with enhanced programmability.
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Use this if you are performing base editing experiments and need to identify specific protein mutations to achieve targeted T-to-G or T-to-C conversions in DNA.
Not ideal if your gene editing needs involve different base changes (e.g., A-to-G, C-to-T) or if you are not working with uracil-N-glycosylase variants.
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Language
Jupyter Notebook
License
MIT
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Last pushed
Jun 06, 2024
Commits (30d)
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