Clair3 and Clair3-RNA
Clair3-RNA is a specialized adaptation of the base Clair3 variant caller specifically optimized for RNA sequencing data, making them complementary tools for different input types rather than competitors.
About Clair3
HKU-BAL/Clair3
Clair3 - Symphonizing pileup and full-alignment for deep learning-based long-read variant calling
This tool helps genetics researchers and genomic scientists accurately identify small genetic variations like SNPs and indels in individual DNA samples using long-read sequencing data. It takes aligned long-read sequencing data (BAM files) as input and produces a list of identified genetic variants (VCF/GVCF files), which are crucial for understanding genetic diseases or population diversity. It is designed for those working with germline variant calling.
About Clair3-RNA
HKU-BAL/Clair3-RNA
Clair3-RNA - a long-read small variant caller for RNA sequencing data
This project helps molecular biologists and geneticists pinpoint small genetic variations (like single letter changes or small insertions/deletions) within RNA sequencing data. You provide raw or aligned long-read RNA sequencing data from platforms like Oxford Nanopore or PacBio, and it outputs a list of these genetic variants. Researchers studying gene expression, RNA editing, or disease mechanisms will find this tool useful.
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