Noble-Lab/HiCFoundation
HiCFoundation is a generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species.
HiCFoundation helps life scientists and genetic researchers understand how the 3D structure of DNA influences gene regulation. You can input Hi-C data, even low-quality or single-cell data, to analyze chromatin architecture, enhance resolution, detect gene loops, and predict epigenomic features. This tool is ideal for biologists, geneticists, and computational biologists studying genome organization across various species.
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Use this if you need to perform in-depth, interpretable analysis of 3D genome architecture and its regulatory functions from Hi-C data, especially when dealing with low-coverage or single-cell experiments, or integrating multi-omics data.
Not ideal if your research does not involve Hi-C data or if you lack access to a CUDA-compatible GPU, which is required for running the model efficiently.
Stars
25
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4
Language
Python
License
Apache-2.0
Category
Last pushed
Aug 23, 2025
Commits (30d)
0
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