Protein-Engineering-Framework/PyPEF
PyPEF – Pythonic Protein Engineering Framework
PyPEF helps protein engineers predict how changes to a protein's amino acid sequence will affect its function or 'fitness.' You provide protein sequences and, optionally, structural data. The framework then uses machine learning, including advanced protein language models, to output predictions of the protein's fitness. This tool is for scientists and researchers in protein engineering and design.
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Use this if you need to rapidly screen and predict the functional outcomes of various protein sequence modifications without extensive lab work.
Not ideal if you are looking for a simple, single-method prediction tool, as this framework offers a range of complex encoding and modeling techniques.
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Python
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Last pushed
Sep 20, 2025
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