comprna/CHEUI
Concurrent identification of m6A and m5C modifications in individual molecules from nanopore sequencing
This tool helps molecular biologists and geneticists identify specific RNA modifications, m6A and m5C, at a single-nucleotide level from Oxford Nanopore direct RNA sequencing data. It takes aligned and resquiggled nanopore sequencing reads (fast5, fastq, bam, nanopolish output) as input. The output provides detailed information on modification presence in individual RNA molecules or differences in modifications between two experimental conditions.
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Use this if you need to precisely detect m6A and m5C RNA modifications and their stoichiometry in individual RNA reads or quantify differential modification levels between samples using Oxford Nanopore sequencing.
Not ideal if you are working with DNA modifications or other RNA modification types beyond m6A and m5C.
Stars
44
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4
Language
C++
License
—
Category
Last pushed
Jul 19, 2024
Commits (30d)
0
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