llnl/protlib-designer
Integer Linear Programming for Protein Library Design
This tool helps protein engineers and researchers design diverse protein variants for experiments or drug discovery. You input a list of potential single-point mutations for a protein, along with scores indicating how desirable each mutation is based on computational models. The tool then outputs a curated list of protein sequences with multiple mutations, optimized to have beneficial properties while maintaining a wide range of variations.
Available on PyPI.
Use this if you need to create a small, highly effective set of diverse protein sequences for experimental testing, starting from computational predictions of individual mutation effects.
Not ideal if you are looking for a tool to predict protein structures, simulate protein dynamics, or analyze existing protein sequences without designing new libraries.
Stars
9
Forks
2
Language
Python
License
MIT
Category
Last pushed
Feb 13, 2026
Commits (30d)
0
Dependencies
4
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