ma-compbio/Higashi
single-cell Hi-C, scHi-C, Hi-C, 3D genome, nuclear organization, hypergraph
Higashi helps computational biologists analyze single-cell Hi-C (scHi-C) data to understand the 3D organization of a genome. It takes raw scHi-C contact maps as input and produces detailed characterizations of 3D genome features, such as TAD-like domain boundaries and A/B compartment scores at a single-cell resolution. This is for researchers in genomics, molecular biology, and computational biology studying chromatin architecture.
Use this if you need to accurately characterize 3D genome features like TADs and A/B compartments from single-cell Hi-C data.
Not ideal if you are working with bulk Hi-C data or other types of genomic sequencing data that are not single-cell Hi-C.
Stars
92
Forks
16
Language
Jupyter Notebook
License
MIT
Category
Last pushed
Oct 29, 2025
Commits (30d)
0
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