ma-compbio/scGHOST
single-cell Hi-C, scHi-C, Hi-C, 3D genome, nuclear organization, genome subcompartment
For molecular biologists and geneticists studying how the 3D structure of a cell's genome impacts its function, scGHOST helps analyze single-cell Hi-C (scHi-C) data. It takes processed scHi-C data from tools like Higashi and identifies distinct 3D organizational patterns (subcompartments) within individual cells. This allows researchers to understand the fine-grained nuclear organization relevant to specific cell types or states.
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Use this if you need to precisely identify and annotate different 3D genomic subcompartments within individual cells from your single-cell Hi-C or single-cell genome imaging data.
Not ideal if you are just starting with raw single-cell Hi-C data and need initial processing or imputation, as scGHOST requires pre-processed inputs.
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MIT
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Last pushed
Apr 08, 2024
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