seqcode/cross-species-domain-adaptation

Codebase for the domain adaptation (cross-species TF binding prediction) project.

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This project helps biological researchers predict where transcription factors (TFs) bind in a new species when they only have training data from a different species. You provide called peak files (genomic regions where TFs bind) from a well-studied species like mouse, and the project outputs predictions for TF binding locations in a less-studied species like human. This is useful for geneticists, molecular biologists, and computational biologists studying gene regulation across different organisms.

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Use this if you need to reliably predict transcription factor binding sites in a target species, but your experimental data is limited to a related, well-characterized species.

Not ideal if you have extensive experimental data for transcription factor binding in the exact species you want to study, as simpler models might suffice.

genomics transcription-factor-binding comparative-genetics gene-regulation bioinformatics
Stale 6m No Package No Dependents
Maintenance 0 / 25
Adoption 5 / 25
Maturity 16 / 25
Community 16 / 25

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Language

Jupyter Notebook

License

MIT

Last pushed

Aug 29, 2022

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