westlake-repl/NRPStransformer
A Transformer-Based Predictor for Nonribosomal Peptide Synthetases (NRPS) Specificity. Published in JACS (DOI: 10.1021/jacs.5c08076).
This tool helps biochemists and synthetic biologists predict the specific amino acid an enzyme (Nonribosomal Peptide Synthetase or NRPS) will attach to a growing peptide chain. You provide a list of protein sequences in a standard FASTA file, and it outputs a CSV file detailing which amino acid each enzyme's adenylation (A) domain is most likely to recognize. This is designed for researchers working with natural product biosynthesis.
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Use this if you need to quickly and accurately determine the substrate specificity of NRPS adenylation domains from their protein sequences.
Not ideal if you are looking for a web-based tool with a simple drag-and-drop interface, as this requires command-line interaction and local setup.
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Python
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MIT
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Last pushed
Sep 11, 2025
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